Preheat your oven to 350°F and spray a 9x5-inch loaf pan with cooking spray.
In a large bowl, mix together the ground beef, V8 juice, taco seasoning, diced onion, eggs, crushed tortilla chips, and 2 cups of the shredded cheese. Get your hands in there — it's the most efficient way.
Press the meat mixture into your prepared loaf pan, making sure it's evenly distributed.
Bake for 30 minutes.
Remove from oven and sprinkle the remaining cup of cheese over the top.
Return to oven and bake for another 10 minutes until the cheese is melted and the internal temperature reaches 160°F.
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